Will Patton as Avery Sunderland: A prominent businessman in Houma who gives back to the community, yet is determined to harness the power of the swamp for profit.Jeryl Prescott as Madame Xanadu: A blind fortune teller whose psychic abilities can reveal the future.Maria Sten as Liz Tremayne: A local newspaper reporter and bartender who is a close childhood friend of Abby Arcane.Henderson Wade as Matthew Cable: A lawman along with his mother Lucilia, who finds himself in dire straits when supernatural events begin to threaten the town.Bean portrays Holland while Mears portrays Swamp Thing. Andy Bean and Derek Mears as Alec Holland/ Swamp Thing: As the elemental superhero Swamp Thing, Holland struggles with holding onto his humanity while defending the town and the natural world at large.Virginia Madsen as Maria Sunderland: The wife of Avery Sunderland, whose grief over the loss of her daughter Shawna returns with Abby's return home, which draws Maria into the supernatural mysteries of the swamp.

Crystal Reed as Abby Arcane: A CDC doctor investigating a horrific life-threatening epidemic in her hometown.But as powerful forces descend on Houma, intent on exploiting the swamp’s mysterious properties for their own purposes, Abby will discover that the swamp holds mystical secrets, both horrifying and wondrous-and the potential love of her life may not be dead after all. When CDC researcher Abby Arcane returns to her childhood home of Houma, Louisiana, in order to investigate a deadly swamp-borne virus, she develops a surprising bond with scientist Alec Holland-only to have him tragically taken from her.

Swamp Thing by Len Wein